Modulation of aldose reductase activity by aldose hemiacetals
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چکیده
منابع مشابه
Topical aldose reductase inhibitor.
amblyopia: a comprehensive survey of outcome. Eye 1992; 6: 300-4. 7 Lithander J, Sjorstrand J. Anisometropic and strabismic amblyopia in the age group 2 years and above: a prospective study of the results of treatment. retinoscopy by used to screen infants for amblyopia? A longitudinal study of refraction in the first year of life. Polymegathism is a term used to describe increased variability ...
متن کاملThe aldose reductase controversy.
ext to the debate as to whether chronic hyperglycemia is the primary cause of the late vascular complications of diabetes, the longest running controversy among researchers and clinicians studying this disease is the role of the sorbitol pathway, particularly its initial enzymatic step, the reduction of glucose to sorbitol by aldose reductase in the pathogenesis of these complications. Because ...
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Aldose reductase (E.C. 1.1.1.21), an intracellular enzyme of polyol pathway, catalyzes NADPHdependent reduction of glucose to sorbitol. Under normoglycemia, most of the cellular glucose is phosphorylated into glucose-6-phosphate by hexokinase. A minor part of non-phosphorylated glucose enters the polyol pathway, the alternate route of glucose metabolism. However, under hyperglycemia, because of...
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The pomegranate, Punica granatum L., has been the subject of current interest as a medicinal agent with wide-ranging therapeutic indications. In the present study, pomegranate ethanolic seed and hull extracts were tested, in comparison with a commercial sample, for the inhibition of aldose reductase, an enzyme involved in the etiology of diabetic complications. In vitro inhibition of rat lens a...
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ژورنال
عنوان ژورنال: Biochimica et Biophysica Acta (BBA) - General Subjects
سال: 2015
ISSN: 0304-4165
DOI: 10.1016/j.bbagen.2015.07.007